The Brits made a slow start against reigning French Open champions Gustavo Fernandez and Shingo Kunieda in the Louis Armstrong Stadium, but came back to defeat the Argentinian-Japanese partnership 1-6, 6-4, (11-9) after a deciding match tie-break.
Gordon and Alfie, who retained his singles crown, are now six-time Grand Slam doubles champions together, having achieved hat-tricks at both Wimbledon and the US Open.
Gordon said: “It was a really tough match, especially the first set. Gustavo and Shingo played really well, so I’m really glad we managed to fight our way back into it and then played a strong tie-break.
"It’s great that the US Open showcases our sport on the stadium courts. This is our first doubles title together this year, so it’s a good place to do it and thanks to all the coaching team who have helped us this week.
"Hopefully we can come back and make it four in a row next year.”